Stochastic nanoporous gold (NPG) structures gained significant interest in the research community due to their advantages as a lightweight structure with a high surface-to-volume ratio. These properties underscore the importance of optimizing and tailoring the mechanical properties of NPG structures though its topology and geometry. However, a quantitative correlation between structural features and mechanical properties remains elusive. In this study, we perform a systematic study to relate topological descriptors of NPG structures to their mechanical properties, specifically Young’s modulus